rises with muscle mass, so an adult range over-reads a child
Glucose
3.5–5.5 mmol/L (63–99 mg/dL)
newborn above 2.6 mmol/L
Urine sodium / chloride
under 20 mmol/L means the loss is not renal
a high urine chloride points to the kidney or a diuretic
Liver, bone and metabolic
Measure
Reference
Note
ALT / AST
10–40 / 10–45 U/L
GGT
5–35 U/L
up to 200 in the first months of life
Alkaline phosphatase
child 100–400 U/L, higher in the growth spurt
an adult range makes normal childhood bone turnover look like disease
Bilirubin (total)
under 17 µmol/L (1 mg/dL) beyond the newborn period
Conjugated bilirubin
under 17 µmol/L, or under 20 percent of total
above this is always pathological
Albumin
35–50 g/L
Cholesterol / triglycerides
total cholesterol under 4.4 mmol/L, triglycerides under 1.5 mmol/L
both rise steeply in nephrotic syndrome, in proportion to the albumin loss
Total protein
60–80 g/L
albumin plus globulin – a low total with a low albumin points to loss rather than to synthesis
INR / prothrombin time
INR 0.8–1.2
the earliest measure of failing liver synthesis, and it does not correct with vitamin K once the liver is the problem
Creatine kinase
under 200 U/L
thousands mean muscle: a Duchenne CK runs 10 000 to 20 000 from infancy
Ammonia
newborn under 110, child under 50 µmol/L
Calcium / magnesium / phosphate
2.2–2.7 / 0.7–1.0 / 1.2–2.0 mmol/L
phosphate runs higher in infancy, to about 2.6
Lipase or amylase
three times the upper limit defines pancreatitis
Sweat chloride
under 30 normal, 30–59 intermediate, 60 or more diagnostic
Caeruloplasmin
0.2–0.6 g/L
low in Wilson disease, and it is an acute phase protein, so a normal level during inflammation does not exclude it
Parathyroid hormone
1.6–7.5 pmol/L
rises early in chronic kidney disease, before calcium or phosphate move
Antistreptolysin O titre
under 200 IU/mL in most children
peaks 3–6 weeks after a streptococcal throat infection; a single raised value shows exposure, not active disease
Malaria parasitaemia
any level is abnormal
above 2 percent counts as severe in a non-immune child, and above 10 percent is an indication for exchange transfusion in some protocols
Endocrine and hormones
Measure
Reference
Note
Thyroid stimulating hormone
0.5–5.0 mIU/L beyond the newborn period
it surges to 20 or more in the first days of life, so a newborn screen is read against its own threshold and not against this range
Free T4
12–22 pmol/L
a low free T4 with a high TSH is primary hypothyroidism; a low free T4 with a low or normal TSH points to the pituitary
Cortisol
morning 140–500 nmol/L
the value only means something beside the time and the clinical state: under 100 during hypoglycaemia or shock is inappropriately low
ACTH
2–11 pmol/L (10–50 ng/L)
high with a low cortisol is adrenal failure; high with a high cortisol points above the adrenal
17-hydroxyprogesterone
under 10 nmol/L after the first few days
grossly raised in 21-hydroxylase deficiency, and the newborn screening analyte for congenital adrenal hyperplasia
Growth hormone / IGF-1
a random growth hormone is uninterpretable; peak over 7 µg/L on provocation is normal
IGF-1 is read against age and pubertal stage, and is low in malnutrition as well as in deficiency
LH / FSH
prepubertal under 0.3 IU/L
an LH above 0.3 with a pubertal response to stimulation means the axis has switched on, which is what separates central from peripheral puberty
Testosterone / oestradiol
prepubertal testosterone under 0.5 nmol/L, oestradiol under 20 pmol/L
HbA1c
under 42 mmol/mol (6.0 percent)
48 mmol/mol (6.5 percent) or more is diagnostic of diabetes; it is unreliable when red cell survival is shortened
Insulin / C-peptide
should be undetectable when glucose is low
any measurable insulin during a hypoglycaemic episode is abnormal and is the whole diagnosis in hyperinsulinism
Ketones (blood)
under 0.6 mmol/L
3.0 or more with acidosis defines ketoacidosis; absent ketones during hypoglycaemia is the abnormal finding, not a reassuring one
25-hydroxyvitamin D
sufficient above 50, deficient below 25 nmol/L
this is the storage form and the one to measure; the active 1,25 form can be normal or high in nutritional rickets
Plasma metanephrines
any clear elevation is abnormal
the screening test for a catecholamine-secreting tumour; caffeine and several drugs raise it falsely
Renin / aldosterone
both read against sodium intake and posture
renin rises in salt-losing states and is suppressed when mineralocorticoid excess is driving the blood pressure
Metabolic screening
Measure
Reference
Note
Anion gap
8–16 mmol/L
sodium minus chloride and bicarbonate. Above 16 means an unmeasured acid: lactate, ketones, an organic acid or a toxin
Uric acid
0.12–0.35 mmol/L (2–6 mg/dL) in children
high in tumour lysis, renal failure and several inborn errors; low in molybdenum cofactor deficiency
Plasma phenylalanine
under 120 µmol/L
the newborn screening analyte; treatment is started above about 360 µmol/L and the level guides dietary control
Plasma amino acids / urine organic acids
qualitative
the PATTERN names the disorder rather than any single value, and the sample must be taken during the acute illness to be interpretable
Tumour markers
Marker
Reference
Note
Alpha-fetoprotein
adult and child under 10 ng/mL (under 8 kU/L)
very high at birth and falls to the adult range by about 8 months, so a neonatal value must be read against age; raised in hepatoblastoma, yolk sac tumour and germ cell tumours
Urinary catecholamines
homovanillic and vanillylmandelic acid, reported against urinary creatinine
raised in about nine in ten neuroblastomas, which is why the urine test comes before any biopsy
Immunology and coeliac serology
Measure
Reference
Note
Total IgA
see age note
1–3 years 0.2–1.0, 4–6 years 0.3–1.3, school age 0.5–2.0, adult 0.8–3.0 g/L. Selective IgA deficiency is under 0.07 g/L
IgG / IgM
IgG 5–16 g/L, IgM 0.5–2.0 g/L beyond infancy
IgG falls to a physiological trough at 3–6 months as maternal antibody clears
Tissue transglutaminase IgA
negative under 7 U/mL; 10x the upper limit supports coeliac disease
it is an IgA antibody, so it reads falsely negative when total IgA is low – always check the total IgA beside it
C3 / C4
C3 0.75–1.65 g/L, C4 0.14–0.54 g/L
a low C3 that recovers by 8–12 weeks is post-infectious nephritis; one that stays low beyond that points to C3 glomerulopathy or membranoproliferative disease, and a low C4 alongside it suggests lupus
Cerebrospinal fluid
Measure
Newborn
Child
White cells
0–20 /mm3
0–5 /mm3
Protein
0.4–1.2 g/L
0.15–0.45 g/L
Glucose
at least 60 percent of the blood glucose
at least 60 percent of the blood glucose
Bacterial pattern
hundreds to thousands of neutrophils, high protein, low glucose
same
Case Complete
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ENT and Ophthalmology – Exam Review Set 1 in 50 board-style clinical cases with worked explanations. Each case gives you a clinical vignette, four options, the correct answer, and an explanation of why each of the other three is wrong, with the guideline or textbook it follows named on the answer.
Board-style teaching questions for paediatricians and trainees preparing for paediatric board, MRCPCH and licensing examinations. Written from published guidelines and standard paediatric textbooks, with the source named on every answer.
The 50 cases, in order
Which mark is which
What the axes mean
Which route wins
The two traces agree
Where the loss sits
It lights up
If it is left alone
Press on the gland
Which one does not count
Not yet
The newborn screen
The commonest cause
Pull the ear
Three days, no better
No canal to use
A torch and a glance
It only looks like one
How to be sure
Naming the turn
Before any surgery
Green, and one side
The commonest lump
Before assuming benign
When it is not benign
What the wait is for
Where it starts
A visible vessel
Stopping the next one
When to look further
A week afterwards
Open it, do not chase it
Swells at the meal
Find it first
Where the gland began
The operation has a name
After the platinum
Put a number on it
Two signs, one nerve
When it crosses over
Scan comes first
Chemical in the eye ten minutes ago
A white pupil in a photograph
A grey reflex at six months
Struggling to see the board
Blurred discs and morning headache
Painful loss of vision in one eye
A lid that has always drooped
A squint worse at close range
A red lump on the eyelid
Blood inside the eye after a ball
Diagnoses and management options tested
Across the fifty cases you are asked to choose between options such as: A cross for the right ear, A wide gap between the two traces, Recurrent infection, Review in about three months, Fever above 39, Visual acuity testing, An exotropia, turning outwards, A pleomorphic adenoma, Because the family must consent formally first, A decongestant spray, Marsupialisation, The foramen caecum of the tongue, Mild hearing loss, Excision in day surgery.
Clinical pearls from this deck
Read the key before the curves. An audiogram interpreted with the ears the wrong way round is a confident answer about the wrong side of the head.
The vertical axis is upside down so the chart looks like the hearing. Down the page means worse, which is why a normal audiogram is a line across the top.
Air goes through everything and bone skips to the end. Once you hold that, every audiogram pattern follows from comparing the two.
Test hearing early after meningitis, not at the follow-up appointment. The cochlea can ossify while everyone is waiting to see whether the hearing recovers.
The gap is the diagnosis. Measure the distance between the two traces and you have both the site of the lesion and the size of the problem.
Take a torch to a neck lump in a baby. A swelling that glows is full of clear fluid, and in the posterior triangle that answers the question on the spot.
Work through the deck once for recognition, then again a week later to test yourself — each question gives the answer and explains why every other option fails.