rises with muscle mass, so an adult range over-reads a child
Glucose
3.5–5.5 mmol/L (63–99 mg/dL)
newborn above 2.6 mmol/L
Urine sodium / chloride
under 20 mmol/L means the loss is not renal
a high urine chloride points to the kidney or a diuretic
Liver, bone and metabolic
Measure
Reference
Note
ALT / AST
10–40 / 10–45 U/L
GGT
5–35 U/L
up to 200 in the first months of life
Alkaline phosphatase
child 100–400 U/L, higher in the growth spurt
an adult range makes normal childhood bone turnover look like disease
Bilirubin (total)
under 17 µmol/L (1 mg/dL) beyond the newborn period
Conjugated bilirubin
under 17 µmol/L, or under 20 percent of total
above this is always pathological
Albumin
35–50 g/L
Cholesterol / triglycerides
total cholesterol under 4.4 mmol/L, triglycerides under 1.5 mmol/L
both rise steeply in nephrotic syndrome, in proportion to the albumin loss
Total protein
60–80 g/L
albumin plus globulin – a low total with a low albumin points to loss rather than to synthesis
INR / prothrombin time
INR 0.8–1.2
the earliest measure of failing liver synthesis, and it does not correct with vitamin K once the liver is the problem
Creatine kinase
under 200 U/L
thousands mean muscle: a Duchenne CK runs 10 000 to 20 000 from infancy
Ammonia
newborn under 110, child under 50 µmol/L
Calcium / magnesium / phosphate
2.2–2.7 / 0.7–1.0 / 1.2–2.0 mmol/L
phosphate runs higher in infancy, to about 2.6
Lipase or amylase
three times the upper limit defines pancreatitis
Sweat chloride
under 30 normal, 30–59 intermediate, 60 or more diagnostic
Caeruloplasmin
0.2–0.6 g/L
low in Wilson disease, and it is an acute phase protein, so a normal level during inflammation does not exclude it
Parathyroid hormone
1.6–7.5 pmol/L
rises early in chronic kidney disease, before calcium or phosphate move
Antistreptolysin O titre
under 200 IU/mL in most children
peaks 3–6 weeks after a streptococcal throat infection; a single raised value shows exposure, not active disease
Malaria parasitaemia
any level is abnormal
above 2 percent counts as severe in a non-immune child, and above 10 percent is an indication for exchange transfusion in some protocols
Endocrine and hormones
Measure
Reference
Note
Thyroid stimulating hormone
0.5–5.0 mIU/L beyond the newborn period
it surges to 20 or more in the first days of life, so a newborn screen is read against its own threshold and not against this range
Free T4
12–22 pmol/L
a low free T4 with a high TSH is primary hypothyroidism; a low free T4 with a low or normal TSH points to the pituitary
Cortisol
morning 140–500 nmol/L
the value only means something beside the time and the clinical state: under 100 during hypoglycaemia or shock is inappropriately low
ACTH
2–11 pmol/L (10–50 ng/L)
high with a low cortisol is adrenal failure; high with a high cortisol points above the adrenal
17-hydroxyprogesterone
under 10 nmol/L after the first few days
grossly raised in 21-hydroxylase deficiency, and the newborn screening analyte for congenital adrenal hyperplasia
Growth hormone / IGF-1
a random growth hormone is uninterpretable; peak over 7 µg/L on provocation is normal
IGF-1 is read against age and pubertal stage, and is low in malnutrition as well as in deficiency
LH / FSH
prepubertal under 0.3 IU/L
an LH above 0.3 with a pubertal response to stimulation means the axis has switched on, which is what separates central from peripheral puberty
Testosterone / oestradiol
prepubertal testosterone under 0.5 nmol/L, oestradiol under 20 pmol/L
HbA1c
under 42 mmol/mol (6.0 percent)
48 mmol/mol (6.5 percent) or more is diagnostic of diabetes; it is unreliable when red cell survival is shortened
Insulin / C-peptide
should be undetectable when glucose is low
any measurable insulin during a hypoglycaemic episode is abnormal and is the whole diagnosis in hyperinsulinism
Ketones (blood)
under 0.6 mmol/L
3.0 or more with acidosis defines ketoacidosis; absent ketones during hypoglycaemia is the abnormal finding, not a reassuring one
25-hydroxyvitamin D
sufficient above 50, deficient below 25 nmol/L
this is the storage form and the one to measure; the active 1,25 form can be normal or high in nutritional rickets
Plasma metanephrines
any clear elevation is abnormal
the screening test for a catecholamine-secreting tumour; caffeine and several drugs raise it falsely
Renin / aldosterone
both read against sodium intake and posture
renin rises in salt-losing states and is suppressed when mineralocorticoid excess is driving the blood pressure
Metabolic screening
Measure
Reference
Note
Anion gap
8–16 mmol/L
sodium minus chloride and bicarbonate. Above 16 means an unmeasured acid: lactate, ketones, an organic acid or a toxin
Uric acid
0.12–0.35 mmol/L (2–6 mg/dL) in children
high in tumour lysis, renal failure and several inborn errors; low in molybdenum cofactor deficiency
Plasma phenylalanine
under 120 µmol/L
the newborn screening analyte; treatment is started above about 360 µmol/L and the level guides dietary control
Plasma amino acids / urine organic acids
qualitative
the PATTERN names the disorder rather than any single value, and the sample must be taken during the acute illness to be interpretable
Tumour markers
Marker
Reference
Note
Alpha-fetoprotein
adult and child under 10 ng/mL (under 8 kU/L)
very high at birth and falls to the adult range by about 8 months, so a neonatal value must be read against age; raised in hepatoblastoma, yolk sac tumour and germ cell tumours
Urinary catecholamines
homovanillic and vanillylmandelic acid, reported against urinary creatinine
raised in about nine in ten neuroblastomas, which is why the urine test comes before any biopsy
Immunology and coeliac serology
Measure
Reference
Note
Total IgA
see age note
1–3 years 0.2–1.0, 4–6 years 0.3–1.3, school age 0.5–2.0, adult 0.8–3.0 g/L. Selective IgA deficiency is under 0.07 g/L
IgG / IgM
IgG 5–16 g/L, IgM 0.5–2.0 g/L beyond infancy
IgG falls to a physiological trough at 3–6 months as maternal antibody clears
Tissue transglutaminase IgA
negative under 7 U/mL; 10x the upper limit supports coeliac disease
it is an IgA antibody, so it reads falsely negative when total IgA is low – always check the total IgA beside it
C3 / C4
C3 0.75–1.65 g/L, C4 0.14–0.54 g/L
a low C3 that recovers by 8–12 weeks is post-infectious nephritis; one that stays low beyond that points to C3 glomerulopathy or membranoproliferative disease, and a low C4 alongside it suggests lupus
Cerebrospinal fluid
Measure
Newborn
Child
White cells
0–20 /mm3
0–5 /mm3
Protein
0.4–1.2 g/L
0.15–0.45 g/L
Glucose
at least 60 percent of the blood glucose
at least 60 percent of the blood glucose
Bacterial pattern
hundreds to thousands of neutrophils, high protein, low glucose
same
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Vaccines – Exam Review Set 3 in 50 board-style clinical cases with worked explanations. Each case gives you a clinical vignette, four options, the correct answer, and an explanation of why each of the other three is wrong, with the guideline or textbook it follows named on the answer.
Board-style teaching questions for paediatricians and trainees preparing for paediatric board, MRCPCH and licensing examinations. Written from published guidelines and standard paediatric textbooks, with the source named on every answer.
The 50 cases, in order
One jab before the winter
Protecting a baby not yet born
Can the bed net go
Who the vaccine is for
Falling, then rising again
Behind, and about to be discharged
No antibody, then a steep rise
Too young, in an outbreak
What the room needs
On steroid, and boosters due
The needle was too short
The fridge that read wrong
One ingredient, and one question
A band that stops at the midline
Thirty spots, and no fever
A dose before the needle
A boy who bleeds, and jabs due
What will hurt least
Why that salt is in there
What happens after the injection
Ninety-one per cent, and cases anyway
Three moves, and no papers
A hundred and four per cent
Forty who did not come
A record before the first day
Small, and the clock running
Unbooked, and nothing known
Still an inpatient, and due
Nine days old, and rigid
A mother still infectious
Pale and floppy, then fine
Four hours of crying
One injection or two
The one that does stop a dose
A lump two months later
A different box on the shelf
A skin test and a live vaccine
An operation in nine days
A card, and a memory
Why again, at fourteen
Fasting, and a dose overdue
Three missed appointments
One at a time, please
What happened at the blood test
Will the standard one do
He caught what he was not given
The last clinic before adult care
Two hours, and no fridge
Yes to four, not to the fifth
He has already had it
Diagnoses and management options tested
Across the fifty cases you are asked to choose between options such as: Passive protection, Any child over nine years of age, He responded once and the protection has since waned, Everything due may be given today as scheduled, Tell him the ingredient lists are not accurate, Do not give it beforehand; treat fever if it occurs, It keeps the antigen stable during freezing, Give only the vaccines due at their current ages, Support it only if exclusion from school is enforced, Withhold it until discharge, Complete the course; this does not contraindicate it, Complete every remaining dose exactly as scheduled, Next week, The course was given incorrectly.
Clinical pearls from this deck
Given antibody is borrowed, not learned. No booster, no schedule slot, and it fades before the next winter.
Protect the baby through the mother when his own response would arrive too late. The window in pregnancy is the whole trick.
A partial vaccine explained as a complete one costs lives. Say the net stays, in the same breath as the offer.
Here the question is not who is at risk, but what the immune system has already met. Test before you offer.
Read the coverage before you blame the programme. High coverage with new serotypes is replacement, not failure.
The child is in front of you and the fridge is down the corridor. That is the whole argument.
Work through the deck once for recognition, then again a week later to test yourself — each question gives the answer and explains why every other option fails.