McCune-Albright Syndrome – Board-Style Questions

What this deck covers

McCune-Albright syndrome in 18 board-style clinical cases with worked explanations. Each case gives you a clinical vignette, four options, the correct answer, and an explanation of why each of the other three is wrong, with the guideline or textbook it follows named on the answer.

Board-style teaching questions for paediatricians and trainees preparing for paediatric board, MRCPCH and licensing examinations. Written from published guidelines and standard paediatric textbooks, with the source named on every answer.

The 18 cases, in order

1. Bleeding at five
2. A negative blood test
3. Brothers and sisters
4. A large cyst
5. Repeated episodes
6. A change in the pattern
7. The boys
8. How much bone
9. Fractures and pain
10. Bone pain
11. A thyroid that won’t settle
12. Too much growth hormone
13. Around the optic nerve
14. A round-faced baby
15. Jaundice in infancy
16. A lump that grows
17. A well young woman
18. The skin marks

Diagnoses and management options tested

Across the 18 cases you are asked to choose between options such as: Early activation of the hypothalamus and pituitary gland together, Testing affected tissue, as blood may miss the variant, One in two, as the condition is inherited as a dominant trait, Remove the ovary to stop the puberty, Letrozole to block oestrogen production, Letrozole has stopped working, No assessment, as boys are unaffected, A CT scan of the femur only, FGF23 from dysplastic bone causing phosphate wasting, They heal the lesions, It remits within two years, Transsphenoidal surgery through the dysplastic skull base, Observation with regular eye checks, A pituitary tumour.

Clinical pearls from this deck

• Suppressed LH and FSH with an ovarian cyst: autonomous ovary.
• Mosaic variant: blood can be negative; test the tissue.
• McCune-Albright syndrome: sporadic, so siblings are not at risk.
• Ovarian cyst in McCune-Albright syndrome: keep the ovary.
• Persistent peripheral puberty in McCune-Albright syndrome: letrozole.
• Rising LH after peripheral puberty: secondary central activation.

Work through the deck once for recognition, then again a week later to test yourself — each question gives the answer and explains why every other option fails.

More from this system: all Endocrinology Board Questions case decks · pediatric reference values.