Chronic Granulomatous Disease – Board-Style Questions

What this deck covers

Chronic granulomatous disease in 18 board-style clinical cases with worked explanations. Each case gives you a clinical vignette, four options, the correct answer, and an explanation of why each of the other three is wrong, with the guideline or textbook it follows named on the answer.

Board-style teaching questions for paediatricians and trainees preparing for paediatric board, MRCPCH and licensing examinations. Written from published guidelines and standard paediatric textbooks, with the source named on every answer.

The 18 cases, in order

1. Abscesses in odd places
2. Measuring the burst
3. Where the fault sits
4. Two peaks on the printout
5. Chest shadows that will not shift
6. A tender spot under the ribs
7. An organism from the soil
8. Vomiting everything back
9. An arm he will not use
10. The tablet taken every day
11. The second daily medicine
12. An injection three times a week
13. Treating inflammation, not infection
14. A node that keeps coming back
15. A gentler course in a girl
16. Which injections he can still have
17. A temperature at ten at night
18. The one thing that ends it

Diagnoses and management options tested

Across the 18 cases you are asked to choose between options such as: Cyclical neutropenia, Dihydrorhodamine flow cytometry showing no oxidative burst, An autosomal recessive defect of a cytosolic component, The laboratory has mixed up two samples, Invasive aspergillosis, Amoebic liver abscess acquired abroad, Escherichia coli, A swallowed foreign body lodged in the stomach, Serratia marcescens osteomyelitis, Amoxicillin taken only during illness, Nystatin drops given after each feed, A daily oral corticosteroid at a low dose, Corticosteroids to settle the obstructing lesion, Reactive lymphadenopathy after a viral illness.

Clinical pearls from this deck

• Deep abscess with normal neutrophils: think CGD.
• The burst test is read one cell at a time.
• Two in three cases are the X-linked subunit.
• A carrier shows two neutrophil populations.
• Mould in the lung is the main danger in CGD.
• Liver abscess in CGD is usually staphylococcal.

Work through the deck once for recognition, then again a week later to test yourself — each question gives the answer and explains why every other option fails.

More from this system: all rheumatology and immunology case decks · pediatric reference values.